Bioactive Alkaloids from the Plant Endophytic Fungus Aspergillus terreus

Abstract

One new alkaloid, named 16α-hydroxy-5 N-acetylardeemin (1), along with seven known metabolites (2–8) was isolated from the fermentation broth of an endophytic fungus, Aspergillus terreus. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis and by comparing spectroscopic data with those in the literature. Compound 1 displayed an inhibitory effect against acetylcholinesterase. Compounds 1–8 also showed moderate or weak cytotoxic activity against KB and HSC‐T6 cell lines.

Key words

Aspergillus terreus - Moniliaceae - cytochalasin - ardeemin - acetylcholinesterase inhibitor - cytotoxic activity

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