Isoflavonoids from the Roots of Campylotropis hirtella

Abstract

From the dried roots of Campylotropis hirtella (Franch.) Schindl., five novel isoflavonoids, 3(S)-7,2′,4′-trihydroxy-5,5′-dimethoxy-6-(3-methylbut-2-enyl)-isoflavan (1), 3(S)-2′,4′-dihydroxy-5,5′-dimethoxy-(6′′,6′′-dimethylpyrano)-(2′′,3′′:7,6)-isoflavan (2), 3(R)-5,4′-dihydroxy-2′-methoxy-3′-(3-methylbut-2-enyl)-(6′′,6′′-dimethylpyrano)-(7,6 : 2′′,3′′)-isoflavanone (3), 3(R)-5,4′-dihydroxy-2′-methoxy-(6′′,6′′-dimethylpyrano)-(7,6: 2′′,3′′)-isoflavanone (4), and 3(R)-5,4′-dihydroxy-7,2′-dimethoxy-6-geranylisoflavanone (5) were isolated. The structures of the compounds were elucidated on the basis of spectroscopic analysis. All isolates exhibited good immunosuppressive activities on mitogen-induced splenocyte proliferation, and their cytotoxicity on splenic lymphocytes was also tested.

Key words

Campylotropis hirtella - Leguminosae - isoflavonoids - immunosuppressive activities

References

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