Cytotoxic and Anti-infective Sesquiterpenes Present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae)

José C. Aponte; Han Yang; Abraham J. Vaisberg; Denis Castillo; Edith Málaga; Manuela Verástegui; Lavona K. Casson; Nicole Stivers; Paula J. Bates; Rosario Rojas; Irma Fernandez; Walter H. Lewis; César Sarasara; Michel Sauvain; Robert H. Gilman; Gerald B. Hammond

doi:10.1055/s-0029-1240681

Planta Medica, Table of Contents

Planta Med 2010; 76(7): 705-707
DOI: 10.1055/s-0029-1240681

Pharmacology

Letters
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic and Anti-infective Sesquiterpenes Present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae)

José C. Aponte¹ , Han Yang¹ , Abraham J. Vaisberg² , Denis Castillo² , Edith Málaga² , Manuela Verástegui² , Lavona K. Casson³ , Nicole Stivers³ , Paula J. Bates³ , Rosario Rojas⁴ , Irma Fernandez⁴ , Walter H. Lewis⁵ , César Sarasara⁶ , Michel Sauvain⁷ , Robert H. Gilman⁸ , Gerald B. Hammond¹

¹Department of Chemistry, University of Louisville, Louisville, KY, USA
²Departamento de Microbiología y Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
³James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
⁴Departamento de Ciencias Farmacéuticas y Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
⁵Department of Biology, Washington University, St. Louis, MO, USA
⁶Confederacion de Nacionalidades Amazónicas del Perú, Lima, Perú
⁷Université de Toulouse III, UMR 152 Mission IRD, Toulouse, France
⁸Johns Hopkins School of Public Health, Baltimore, MD, USA

Abstract

A pharmacological screening of the ethanol extract and fractions of two Peruvian medicinal plants, Plagiochila disticha and Ambrosia peruviana, led to the isolation and characterization of three ent-2,3-secoaromadendrane-type sesquiterpenoids, named plagiochiline A (1), I (2), and R (3), as well as of two pseudoguaianolids, damsin (4) and confertin (5), which exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 1, 4, and 5 were also investigated for their in vitro antileishmanial, trypanocidal, and antituberculosis activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes, as well as against MDR and sensitive strains of Mycobacterium tuberculosis, respectively.

Supporting information available online at http://www.thieme-connect.de/ejournals/toc/plantamedica

Key words

Plagiochila disticha - Plagiochilaceae - Ambrosia peruviana - Asteraceae - antileishmania - trypanoside - tuberculosis - cytotoxic

Full Text

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Univ.-Prof. Dr. Gerald Hammond

Department of Chemistry
University of Louisville

2320 S. Brook Street

Louisville, KY 40292

USA

Phone: + 1 50 28 52 59 98

Fax: + 1 50 28 52 38 99

Email: gb.hammond@louisville.edu

Supplementary Material

www.thieme-connect.de/ejournals/toc/plantamedica