Genome wide association study on cognitive performance

B Konte; I Giegling; AM Hartmann; H Konnerth; P Muglia; A Ruppert; HJ Möller; D Rujescu

doi:10.1055/s-0029-1240158

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Pharmacopsychiatry 2009; 42 - A86
DOI: 10.1055/s-0029-1240158

Genome wide association study on cognitive performance

B Konte ¹, I Giegling ¹, AM Hartmann ¹, H Konnerth ¹, P Muglia ², A Ruppert ³, HJ Möller ¹, D Rujescu ¹

¹Department of Psychiatry, University of Munich
²GSK, Munich, Germany
³GRC, Munich, Germany

Congress Abstract

There is evidence for a strong genetic component in cognitive performance as demonstrated by family, twin and adoption studies. The mode of inheritance is complex, involving the combined action of several genes, each of which might account for only a small effect. Several complementary strategies are needed to approach the genetics of cognition including genetic association studies as well as animal and cell culture models. We first aimed to identify cognition genes in a large community-based sample. 2500 probands were included. A genome-wide association study was performed in 500 probands and several replication steps followed. The poster will present these new results and discuss them.