No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms

G Koller; P Zill; O Pogarell; B Bondy; M Soyka

doi:10.1055/s-0029-1240155

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Pharmacopsychiatry 2009; 42 - A83
DOI: 10.1055/s-0029-1240155

No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms

G Koller ¹, P Zill ¹, O Pogarell ¹, B Bondy ¹, M Soyka ²

¹Klinik für Psychiatrie und Psychotherapie der LMU, Munich, Germany
²Privatklinik Meiringen, Switzerland

Congress Abstract

To determine whether glycine transporter polymorphisms are associated with alcoholism, 3 genetic variants of SLC6A5 and 2 polymorphisms of SLC6A9 were genotyped in 463 German non-alcoholic controls and 644 German alcohol-dependent subjects. Association was investigated employing chi-square statistics and haplotype analysis. There was a significant association between the SLC6A5 polymorphism (rs1443547) and alcohol dependence as alcoholic individuals had a lower rate of AG-allele (Chi²=6.048, p=0.049, df=2), which did not remain significant after correction for multiple testing. There was no an association between SLC6A9 glycine transporter polymorphisms and alcohol dependence, and also not in haplotype analysis.