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Int J Sports Med 2010; 31(1): 65-71
DOI: 10.1055/s-0029-1239523
Genetics & Molecular Biology

© Georg Thieme Verlag KG Stuttgart · New York

ACE DD Genotype is Unfavorable to Korean Short-Term Muscle Power Athletes

C.-H. Kim1 , J.-Y. Cho2 , J. Y. Jeon3 , Y. G. Koh4 , Y.-M. Kim5 , H.-J. Kim6 , M. Park7 , H.-S. Um2 , C. Kim1
  • 1Eulji University School of Medicine, Physiology and Biophysics, Daejoen, Korea, Republic of Korea
  • 2Korean National Sport University, Exercise Biochemistry, Seoul, Korea, Republic of Korea
  • 3Yonsei university, Department of Sport and Leisure Studies, Seoul, Korea, Republic of Korea
  • 4Yonsei Sarang Hospital, Cartilage Regeneration and Sports Medicine, Seoul, Korea, Republic of Korea
  • 5Korea Sports Council & Korean Olympic Committee, Sports Development, Seoul, Korea, Republic of Korea
  • 6Soonchunhyang University, Measurement and Evaluation in Sports Science, Asan, Korea, Republic of Korea
  • 7Eulji University School of Medicine, Biostatistics, Seoul, Korea, Republic of Korea
Further Information

Publication History

accepted after revision August 06, 2009

Publication Date:
22 December 2009 (online)

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Abstract

The purpose of this study was to test the hypothesis that the ACE DD genotype is unfavorably associated with the ultimate power-oriented performance. To test the hypothesis we recruited a total of 848 subjects including 55 international level power-oriented athletes (High-performance), 100 national level power-oriented athletes (Mid-performance) and 693 healthy controls (Control) in Korea. Then the distributions of ACE polymorphism throughout these groups were analyzed. As a result, there was a gradual decrease of frequencies of the DD genotype with advancing levels of performance (Control vs. Mid-performance vs. High-performance=17.2% vs. 10.0% vs. 5.5%, p=0.002). Also, the frequencies of D allele decreased gradually with advancing levels of performance (Control vs. Mid-performance vs. High-performance=42.6% vs. 35.0% vs. 30.9%, p<0.01). Therefore, power-oriented athletes at the top level had a markedly diminished frequency of the DD genotype and the D allele. This finding gave 3.83 times lower probability of success in power-oriented sports for individuals with the DD genotype than those with the II+ID genotype. In conclusion, these results indicate that Korean power-oriented athletes with a lower frequency of the DD genotype had a lower probability of success in power-oriented sports.

Key words

angiotensin-converting enzyme - population genetics - physical performance - anaerbic muscle power

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Correspondence

Prof. Chan Kim

Eulji University School of Medicine Phyiology and Biophysics 143-5 Yongdu-dong Chung-Gu

301-746 Daejoen

Korea

Republic of Korea

Phone: +82-10-8885-2787

Fax: +82-42-259-1387

Email: kimch37@nate.com

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