Neurocognitive Consequences of Sleep Deprivation

Namni Goel; Hengyi Rao; Jeffrey S Durmer; David F Dinges

doi:10.1055/s-0029-1237117

Seminars in Neurology, Table of Contents

Semin Neurol 2009; 29(4): 320-339
DOI: 10.1055/s-0029-1237117

Neurocognitive Consequences of Sleep Deprivation

Namni Goel¹ , Hengyi Rao¹ , Jeffrey S. Durmer² , David F. Dinges¹

¹Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
²Fusion Sleep, Sleep Medicine Program, Suwanee, Georgia

Abstract

ABSTRACT

Sleep deprivation is associated with considerable social, financial, and health-related costs, in large measure because it produces impaired cognitive performance due to increasing sleep propensity and instability of waking neurobehavioral functions. Cognitive functions particularly affected by sleep loss include psychomotor and cognitive speed, vigilant and executive attention, working memory, and higher cognitive abilities. Chronic sleep-restriction experiments—which model the kind of sleep loss experienced by many individuals with sleep fragmentation and premature sleep curtailment due to disorders and lifestyle—demonstrate that cognitive deficits accumulate to severe levels over time without full awareness by the affected individual. Functional neuroimaging has revealed that frequent and progressively longer cognitive lapses, which are a hallmark of sleep deprivation, involve distributed changes in brain regions including frontal and parietal control areas, secondary sensory processing areas, and thalamic areas. There are robust differences among individuals in the degree of their cognitive vulnerability to sleep loss that may involve differences in prefrontal and parietal cortices, and that may have a basis in genes regulating sleep homeostasis and circadian rhythms. Thus, cognitive deficits believed to be a function of the severity of clinical sleep disturbance may be a product of genetic alleles associated with differential cognitive vulnerability to sleep loss.

KEYWORDS

Neurobehavioral performance - sleep restriction - attention and executive function - functional neuroimaging - prefrontal cortex - thalamus - sensory processing areas - genetics

Full Text

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David F DingesPh.D.

Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine

1013 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021

Email: dinges@mail.med.upenn.edu