Planta Med 2009; 75 - PI13
DOI: 10.1055/s-0029-1234777

In vitro anti-acne inducing bacteria activity of mangosteen fruit rind extract gel

W Pothitirat 1, P Pithayanukul 2, MT Chomnawang 3, W Gritsanapan 1
  • 1Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
  • 2Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
  • 3Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand

The extract of fruit rind of mangosteen (Garcinia mangostana Linn.) was reported to possess a strong inhibitory effect against Propionibacterium acnes which is a major bacteria involves in acne development [1]. Therefore, it is interesting for developing anti-acne gel preparation from this plant. The ethanolic extract of mangosteen fruit rind was prepared using Soxhlet extraction. Hydro-alcohol gel preparation containing 1% w/w of the extract was formulated. The antibacterial activity of the extract and its preparation against P. acnes was evaluated using broth microdilution method [2]. Based on MIC and MBC values, the extract promoted a good inhibitory effect against P. acnes (MIC=7.81µg/ml, MBC=15.63µg/ml), while the 1%w/w mangosteen fruit rind gel showed similar anti-acne activity with standard 2.5% benzoyl peroxide anti-acne gel (Pan-Oxyl 2.5®gel) at MIC and MBC 1.56mg/ml. The results showed that anti-acne gel with mangosteen fruit rind extract promoted good effect against acne inducing bacteria. The stability of this preparation is being investigated.

Acknowledgements: This study is a part of Ph.D. thesis of Mahidol University and was granted by the University Research Fund.

References: [1] Chomnawang, M.T. et al. (2005)J. Ethnopharmacol. 101:330–333.

[2] NCCLS (2008) Performance Standards for Antimicrobial Susceptibility Testing. Wayne. PA.