Planta Med 2009; 75 - PA80
DOI: 10.1055/s-0029-1234405

Analgesic study of hexanic fraction of Agave sisalana

RJ Dunder 1, A Luiz-Ferreira 1, ACA Almeida 1, FM De Faria 2, C Takayama 1, ARMS Brito 1
  • 1Department. of Physiology and Biophysics UNICAMP, Monteiro Lobato St, 255– Campinas – SP – Brazil – CEP 13083–862
  • 2Department of Pharmacology UNICAMP, Tessália Vieira de Camargo St, 126 Campinas- SP- Brazil CEP 13084–971

The therapeutic use of medicinal plants is widely used throughout the world. It is an ancient tradition in several cultures.

The objective of these tests is to analyze the analgesic property the Hexanic fraction in Agave sisalana (FHAS) with doses of 5, 10, 25 and 50mg/kg. The analgesic investigations were carried out in two types of noxious stimuli: chemically (acetic acid-induced writhing) using a positive control, (indomethacin) and thermal (hot plate and tail flick tests) with morphine and sufentanil control, respectively, and Polietileneglycol 40% (PEG) as vehicle.

FHAS decreased the acetic acid model writhings in doses of 5, 10 and 25mg/kg (22, 54 e 48%, respectively) in comparison with PEG and the standard drug Indomethacin (45%). It showed an increasing latency time in tail flick tests in doses of 10mg/kg (47,4% in 90 minutes), 25mg/kg (61,5% in 60 minutes) and 50mg/kg (66,2 in 45 minutes). Hot Plate showed increasing latency time in 10 (5,91±0,89s), 25 (6,58±0,68s) and 50 (7,49±1,14) doses 120 minutes. These results showed that FHAS had central and peripheral acting effects, but they do not involve an opioid receptor. In conclusion, FHAS has analgesic activity.

Acknowledgements: CAPES, FAPESP