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DOI: 10.1055/s-0029-1234373
α-Glucosidase inhibitors from the leaves of Machilus Philippinensis (II)1
A preliminary screening indicated the EtOH extract of the leaves from Machilus Philippinensis to be active against α-glucosidase [1], which is one of the therapeutic targets in the treatment of diabetes mellitus [2]. Following the bioassay-guided fractionation and separation, five proanthocyanidin oligomers (1-5) and 12 flavonoids were characterized. Of these, two proanthocyanidin oligomers, named machiphilitannins A (1) and B (2) after the plant origin, are new compounds, with respective IC50 values of 31.28 µM (1) and 18.40 µM (2) against α-glucosidase. Their structures were elucidated based mainly on elaborate 2D NMR spectral analysis.
References: [1] For the first report see Lee, S. S. et al. (2008) Phytochemistry 69:2347–2353.
[2]iCheng, A. et al. (2005) Can. Med. Assoc. J. 172:213–226.