Planta Med 2009; 75 - PA48
DOI: 10.1055/s-0029-1234373

α-Glucosidase inhibitors from the leaves of Machilus Philippinensis (II)1

HC Lin 1, SS Lee 1
  • 1School of Pharmacy, College of Medicine, National Taiwan University, 1, Sec. 1, Jen-Ai Rd, Taipei 10051, Taiwan, Republic of China

A preliminary screening indicated the EtOH extract of the leaves from Machilus Philippinensis to be active against α-glucosidase [1], which is one of the therapeutic targets in the treatment of diabetes mellitus [2]. Following the bioassay-guided fractionation and separation, five proanthocyanidin oligomers (1-5) and 12 flavonoids were characterized. Of these, two proanthocyanidin oligomers, named machiphilitannins A (1) and B (2) after the plant origin, are new compounds, with respective IC50 values of 31.28 µM (1) and 18.40 µM (2) against α-glucosidase. Their structures were elucidated based mainly on elaborate 2D NMR spectral analysis.

References: [1] For the first report see Lee, S. S. et al. (2008) Phytochemistry 69:2347–2353.

[2]iCheng, A. et al. (2005) Can. Med. Assoc. J. 172:213–226.