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DOI: 10.1055/s-0029-1225626
© Georg Thieme Verlag KG Stuttgart · New York
Two Cases with Progressive Cystic Leukoencephalopathy
Publikationsverlauf
received 02.02.2009
accepted 07.06.2009
Publikationsdatum:
28. Juli 2009 (online)
Abstract
Leukoencephalopathies with cystic changes in the white matter on magnetic resonance imaging are aetiologically heterogeneous neurological disorders seen in children. A group of leukoencephalopathies characterised by white matter lesions progressing to multifocal cystic degeneration has been reported in various disorders, including mitochondrial enzyme deficiencies, leukodystrophies, and infectious processes. We report two patients with leukoencephalopathy showing progressive cystic changes on serial MRI, and magnetic resonance spectroscopy resembling progressive cavitating leukoencephalopathy.
Key words
progressive cystic leukoencephalopathy - episodic clinical deterioration - lactate in magnetic resonance spectroscopy - mitochondrial leukoencephalopathies - multiple sclerosis - acute disseminated encephalomyelitis
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Correspondence
Prof. Dr. C. Yalcinkaya
Division of Child Neurology
Neurology Department
Cerrahpasa Med. Sch.,
34098 Istanbul
Turkey
Telefon: +90/212/414 3157
Fax: +90/212/632 9696
eMail: cengiz@istanbul.edu.tr