Neuropediatrics 2009; 40(1): 47-51
DOI: 10.1055/s-0029-1225626
Short Communication

© Georg Thieme Verlag KG Stuttgart · New York

Two Cases with Progressive Cystic Leukoencephalopathy

Z. Yapici 1 , G. Benbir 2 , S. Saltik 3 , L. He 4 , G. K. Brown 5 , R. W. Taylor 4 , A. Dincer 6 , S. Naidu 7 , C. Yalcinkaya 2
  • 1Division of Child Neurology, Department of Neurology, Istanbul Medical School, Istanbul University, Istanbul, Turkey
  • 2Division of Child Neurology, Department of Neurology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
  • 3Department of Pediatrics, Goztepe Education Hospital, Istanbul, Turkey
  • 4Mitochondrial Research Group, Institute of Ageing and Health, The Medical School, Newcastle University, Newcastle upon Tyne, UK
  • 5Genetics Unit, Department of Biochemistry, University of Oxford, Oxford, UK
  • 6Department of Radiology, Kozyatagi Acibadem Hospital, Istanbul, Turkey
  • 7Neurogenetics Department, Kennedy Krieger Institute and the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Further Information

Publication History

received 02.02.2009

accepted 07.06.2009

Publication Date:
28 July 2009 (online)


Leukoencephalopathies with cystic changes in the white matter on magnetic resonance imaging are aetiologically heterogeneous neurological disorders seen in children. A group of leukoencephalopathies characterised by white matter lesions progressing to multifocal cystic degeneration has been reported in various disorders, including mitochondrial enzyme deficiencies, leukodystrophies, and infectious processes. We report two patients with leukoencephalopathy showing progressive cystic changes on serial MRI, and magnetic resonance spectroscopy resembling progressive cavitating leukoencephalopathy.



Prof. Dr. C. Yalcinkaya

Division of Child Neurology

Neurology Department

Cerrahpasa Med. Sch.,

34098 Istanbul


Phone: +90/212/414 3157

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