Senologie - Zeitschrift für Mammadiagnostik und -therapie 2009; 6 - A87
DOI: 10.1055/s-0029-1225011

AdipoR1 expression in invasive and preinvasive breast cancer

G Pfeiler 1, G Hudelist 2, P Wülfing 3, R Königsberg 4, E Kubista 1, C Singer 1
  • 1Medizinische Universität Wien, Spezielle Gynäkologie, Wien, Österreich
  • 2Landeskrankenhaus Villach, Abteilung für Gynäkologie und Geburtshilfe, Villach, Österreich
  • 3Universität Münster, Abteilung für Gynäkologie und Geburtshilfe, Münster, Deutschland
  • 4Kaiser Franz Josef Spital, Abteilung für Innere Medizin, Wien, Österreich

Objective: A clear inverse correlation between adiponectin serum level and breast cancer risk has been established. Adiponectin seems to inhibit tumor cell growth mainly via AdipoR1 in some but not all breast cancer cell lines. In the present study we investigated AdipoR1 expression in invasive breast cancer and adjacent as well as non-adjacent preinvasive breast cancer.

Methods: A tissue microarray containing 39 invasive breast cancers with or without adjacent preinvasive component (DCIS) as well as 165 preinvasive breast cancers (DCIS) was established for further analysis. AdipoR1 expression was investigated by immunhistochemistry. A Chi Square test was used to identify differences of AdipoR1 protein expression levels. Spearman's correlation coefficient was used to identify associations between clinical/histopathological tumor parameters and AdipoR1 expression.

Results: Stromal and epithelial AdipoR1 was significantly higher expressed in invasive breast cancer compared to preinvasive DCIS. No difference of AdipoR1 expression could be observed comparing DCIS adjacent to invasive breast cancer with DCIS only. Regarding preinvasive breast cancer, a significant inverse correlation between AdipoR1 expression and size of the lesion could be observed. A significant correlation between AdipoR1 and ER expression could be demonstrated for invasive breast cancer. Menopausal status showed no influence on AdipoR1 expression neither in preinvasive nor in invasive breast cancer

Conclusion: The inverse correlation between AdipoR1 expression and size in preinvasive breast cancer underlines the preclinical data on antitumoral activity of adiponectin.