Neuropediatrics 2009; 40(1): 22-27
DOI: 10.1055/s-0029-1224101
Original Article

© Georg Thieme Verlag KG Stuttgart · New York

Protective Effects of Topiramate against Hyperoxic Brain Injury in the Developing Brain

S. H. Kurul 1 , U. Yiş 1 , A. Kumral 2 , K. Tuğyan 3 , S. Cilaker 3 , E. Kolatan 4 , O. Yılmaz 4 , Ş. Genç 5
  • 1Department of Pediatric Neurology, School of Medicine, Dokuz Eylül University, İnciraltı, İzmir, Turkey
  • 2Department of Neonatology, School of Medicine, Dokuz Eylül University, İnciraltı, İzmir, Turkey
  • 3Department of Histology and Embryology, School of Medicine, Dokuz Eylül University, İnciraltı, İzmir, Turkey
  • 4Animal Research Center, School of Medicine, Dokuz Eylül University, İnciraltı, İzmir, Turkey
  • 5Research Laboratory, School of Medicine, Dokuz Eylül University, İnciraltı, İzmir, Turkey
Further Information

Publication History

received 03.02.2009

accepted 21.04.2009

Publication Date:
28 July 2009 (online)

Abstract

Recent studies have shown that exposure to hyperoxia in infant rats leads to extensive apoptotic degeneration in the cortex and white matter of the developing brain. Besides its antiepileptic effects, topiramate exerts neuroprotective effects in animal models of stroke, hypoxia ischemia, excitotoxic insults, and status epilepticus. In the present study, we investigated the effects of topiramate against hyperoxia-induced neurodegeneration in the developing brain. Eighteen Wistar rat pups were divided into three groups: control group, hyperoxia+phosphate buffered saline treated group and hyperoxia+topiramate treated group. Hyperoxia groups were exposed to 80% oxygen (n=12) in plexiglas chambers in which the oxygen concentration was monitored twice daily from birth until postnatal day five. The hyperoxia+topiramate group received an intraperitoneal injection of topiramate at a dose of 80 mg/kg/day. At postnatal day 5, all animals were killed. Neuronal cell death and apoptosis were evaluated. Histopathological examination showed that topiramate significantly diminished apoptosis in the CA1 region and dentate gyrus of hippocampus. Topiramate may offer a therapeutic potential for neuroprotection under conditions of hyperoxic brain injury.

References

Correspondence

Dr. S. H. Kurul, MD 

Dokuz Eylül University School of Medicine

Department of Pediatrics Division of PediatricNeurology

İnciraltı

35340 İzmir

Turkey

Phone: +90/232/412 36 36

Fax: +90/232/412 36 49

Email: skurul@hotmail.com