Horm Metab Res 2009; 41(8): 605-611
DOI: 10.1055/s-0029-1220736
Original Basic

© Georg Thieme Verlag KG Stuttgart · New York

Decrease of Bone Morphogenetic Protein-7 (BMP-7) and its Type II Receptor (BMP-RII) in Kidney of Type 1-Like Diabetic Rats

C. H. Yeh 1 , 5 , C. K. Chang 2 , M. F. Cheng 3 , H. J. Lin 4 , J. T. Cheng 1 , 4 , 5
  • 1Institute of Basic Medical Sciences and Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
  • 2Department of Surgery, Mackay Memorial Hospital, and Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei City, Taiwan
  • 3Division of Nephrology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City, Taiwan
  • 4Department of Emergency Medicine and Department of Medical Research, Chi-Mei Medical Center, Yung Kang City, Tainan Shen, Taiwan
  • 5Institute of Medical Science, College of Health Science, Chang Jung Christian University, Kway Jean, Tainan, Taiwan, R.O.C.
Further Information

Publication History

received 06.02.2009

accepted 31.03.2009

Publication Date:
13 May 2009 (eFirst)

Abstract

Bone morphogenetic protein-7 (BMP-7) expression is known to be protective for renal damage during diabetic nephropathy and disappears early during the progression of diabetic nephropathy. However, changes in expression of BMP-7 and BMP-7 type II receptor (BMP-RII) during kidney nephropathy response to high glucose-induced oxidative stress remain unclear. In this study, we used streptozotocin-induced diabetic rats with diabetic nephropathy and treated them with insulin, phloridzin, or antioxidant tiron. The insulin, phloridzin, or tiron treatment improved the renal function and decreased fibronectin expression in the streptozotocin-induced diabetic rats. Both insulin and phloridzin could reverse the attenuation effects of hyperglycemia on BMP-7 and BMP-RII expressions in the kidneys of streptozotocin-induced diabetic rats through the correction of hyperglycemia. However, the decrease of BMP-7 and BMP-RII expressions in kidney of streptozotocin-induced diabetic rats could be reversed by tiron through decreasing the high glucose-induced oxidative stress but not through changing the levels of glucose. We further confirmed the effect on reversing the BMP-7 and BMP-RII expressions through decreasing oxidative stress by tiron treatment in high glucose exposed mesangial cells. Thus, we suggest that a decrease in oxidative stress is responsible for the improvement of renal function and recovery of renal BMP-7 and BMP-RII expression in streptozotocin-induced diabetic rats.

References

Correspondence

Prof. J-T. Cheng, PhD, FCP 

Department of Pharmacology

College of Medicine

National Cheng Kung University

Tainan City

70101 Taiwan

Phone: +886/6/237 27 06

Fax: +886/6/238 65 48

Email: jtcheng@mail.ncku.edu.tw