Facial Plast Surg 2009; 25(2): 114-119
DOI: 10.1055/s-0029-1220651
© Thieme Medical Publishers

Soft Tissue Augmentation with ArteFill

John M. Hilinski1 , 2 , Steven R. Cohen3 , 4
  • 1San Diego Face and Neck Specialties, San Diego, California
  • 2Division of Otolaryngology–Head and Neck Surgery, University of California, San Diego, Medical Center, San Diego, California
  • 3Division of Plastic and Reconstructive Surgery, University of California, San Diego, Medical Center, San Diego, California
  • 4FacesPlus Aesthetic Surgery Center, San Diego, California
Further Information

Publication History

Publication Date:
04 May 2009 (online)


ArteFill is a novel, third-generation polymethylmethacrylate (PMMA) injectable filler with unique properties. When compared with predecessor materials, ArteFill demonstrates improved biocompatibility as a result of more uniform PMMA microsphere size and shape. This translates into less adverse events after placement. ArteFill can provide a permanent volume enhancement by stimulation of fibroblasts that encapsulate nonabsorbable microspheres with collagen deposition. Currently, ArteFill is FDA approved for permanent augmentation of moderately deep nasolabial folds. It is also commonly used off-label for augmentation of other skin creases and regional areas of volume deficiency, such as the tear trough–malar and marionette line–prejowl sulcus regions. The key to success with ArteFill is a conservative approach with avoidance of overcorrection. Proper technique includes deep dermal to subcutaneous placement with full correction achieved gradually over several treatments. Complications are mostly limited to nodule formation, which is easily managed in most cases with conservative intervention.


John M Hilinski, M.D. 

Medical Director and Owner, San Diego Face and Neck Specialties

PC, 4111 Randolph Street, San Diego, CA 92103

Email: [email protected]