Synfacts 2010(7): 0804-0804  
DOI: 10.1055/s-0029-1220029
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Asymmetric Hydrogenation of α-Arylmethylene Cycloalkanones

Contributor(s): Hisashi Yamamoto, Patrick Brady
J.-B. Xie, J.-H. Xie*, X.-Y. Liu, W.-L. Kong, S. Li, Q.-L. Zhou*
Nankai University, P. R. of China
Further Information

Publication History

Publication Date:
22 June 2010 (online)

Significance

The authors disclose an efficient entry to chiral cyclic exo-methylene allylic alcohols and applied this method to the synthesis of a key intermediate of the anti-inflammatory agent loxoprofen.