Synfacts 2010(6): 0683-0683  
DOI: 10.1055/s-0029-1219968
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Pyrrolidines by Osmium-Catalyzed Oxidative Cyclization

Contributor(s): Hisashi Yamamoto, Patrick Brady
T. J. Donohoe*, P. J. Lindsay-Scott, J. S. Parker, C. K. A. Callens
University of Oxford and AstraZeneca, Bristol, UK
Further Information

Publication History

Publication Date:
20 May 2010 (online)

Significance

The described method allows for the construction of pyrrolidines by oxidative cycli­zation of amino alcohols that are formally derived from 1,4-dienes. Judicious choice of substrate geometry allows for the construction of both syn- and anti- pyrrolidines.