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Synfacts 2010(6): 0622-0622  
DOI: 10.1055/s-0029-1219851
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of Diazonamide A

Contributor(s): Steven V. Ley, Philippa B. Cranwell
C.-K. Mai, M. F. Sammons, T. Sammakia*
University of Colorado, Boulder, USA
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Publication History

Publication Date:
20 May 2010 (online)

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Significance

Diazonamide A was isolated from colonial ascidian Diazona angulata in 1991. The main synthetic challenge presented by diazon­amide A is the hindered quaternary center at C10. To date, three total syntheses have been developed: one by the Nicolaou group, one by Harran and co-workers, and a formal synthesis by ­Magnus and co-workers.