Synfacts 2010(3): 0314-0314  
DOI: 10.1055/s-0029-1219320
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Gold-Catalyzed Friedel-Crafts Allylic Alkylation of Indoles with Alcohols

Contributor(s): Hisashi Yamamoto, Pingfan Li
M. Bandini*, A. Eichholzer
Universita di Bologna, Italy
Further Information

Publication History

Publication Date:
18 February 2010 (online)


This paper describes a direct chiral bimetallic gold(I)-phosphine complex catalyzed Friedel-Crafts allylic alkylation of indoles with alcohols to give functionalized tetrahydrocarbazoles with good yield and enantioselectivities. A very interesting two-point coordination mode of activation of the allylic alcohol moiety is proposed to account for the success of this reaction.