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Synfacts 2010(3): 0343-0343  
DOI: 10.1055/s-0029-1219310
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Alkylation of Amines and Sulfonamides by Copper(II)-Catalyzed Hydrogen Transfer

Contributor(s): Paul Knochel, Andreas J. Wagner
A. Martínez-Asencio, D. J. Ramón*, M. Yus*
Universidad de Alicante, Spain
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

Copper(II) acetate is shown to be a versatile and cheap catalyst for the selective N-monoalkylation of poorly nucleophilic amines and sulfonamides. This new methodology for the synthesis of primary and secondary amines uses a low-cost and commercially available catalyst and has a broad substrate scope.