Nucleophilic Trifluoromethylation Using Diethyl Trifluoromethanephosphonate

P. Cherkupally; P. Beier

doi:10.1055/s-0029-1219307

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Synfacts 2010(3): 0340-0340
DOI: 10.1055/s-0029-1219307

Metal-Mediated Synthesis

Nucleophilic Trifluoromethylation Using Diethyl Trifluoromethanephosphonate

Contributor(s): Paul Knochel, Andreas J. Wagner
P. Cherkupally, P. Beier*
Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Publication History

Publication Date:
18 February 2010 (online)

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Significance

A novel alkoxide-induced nucleophilic trifluoromethylation of carbonyl compounds, disulfides, and diselenides is presented and a plausible reaction mechanism is discussed. The reagent diethyl trifluoromethanephosphonate herein acts as a [CF₃]^- synthon.