Synthesis of Amines from Alcohols and Urea with Ru(OH)x/TiO2

J. He; J. W. Kim; K. Yamaguchi; N. Mizuno

doi:10.1055/s-0029-1219289

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Synfacts 2010(3): 0363-0363
DOI: 10.1055/s-0029-1219289

Polymer-Supported Synthesis

Synthesis of Amines from Alcohols and Urea with Ru(OH)_x/TiO₂

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
J. He, J. W. Kim, K. Yamaguchi, N. Mizuno*
The University of Tokyo and Japan Science and Technology Agency, Kawaguchi, Japan

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Publication History

Publication Date:
18 February 2010 (online)

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Significance

TiO₂-supported ruthenium hydroxide (Ru(OH)_x/TiO₂) catalyzed the reaction of alcohols 1 with urea in mesitylene under Ar atmosphere to give the corresponding tertiary amines 2 or secondary amines 3 in 76-98% yield (13 examples). The catalyst was recovered by simple filtration and reused without significant loss of catalytic performance for formation of 3k (reuse: 90% yield). No leaching of ruthenium was observed by ICP-AES analysis after the reaction.