Synthesis of Indanes by Enantioselective Direct Arylation

Significance

Transition-metal-catalyzed C-H functionalization reactions are becoming increasingly practical; however, highly enantioselective variants are rare (see Review below). The authors have identified a catalytic system which allows for the desymmetrization of enantiotopic aryl C-H bonds using a palladium-catalyzed direct arylation.