The First Cobalt-Catalyzed
Transformation of Alkynyl C-H Bond: Aldehyde-Alkyne-Amine
(A³) Coupling

Wen-Wen Chen; Hai-Peng Bi; Chao-Jun Li

doi:10.1055/s-0029-1219173

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Synlett 2010(3): 475-479
DOI: 10.1055/s-0029-1219173

LETTER

The First Cobalt-Catalyzed Transformation of Alkynyl C-H Bond: Aldehyde-Alkyne-Amine (A^³) Coupling

Wen-Wen Chen, Hai-Peng Bi, Chao-Jun Li*
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 2K6, Canada
e-Mail: cj.li@McGill.ca;

Further Information

Publication History

Received 25 September 2009
Publication Date:
07 January 2010 (online)

Abstract
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Abstract

The first highly effective cobalt-catalyzed reaction of terminal alkynes was developed. The reaction of alkynes with aldehyde and amine generated a diverse range of propargyl amines in excellent yields by this method.

Key words

cobalt-catalyzed - aldehyde-alkyne-amine coupling - A^³ coupling - alkynyl C-H activation

References and Notes

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