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Synfacts 2010(2): 0206-0206  
DOI: 10.1055/s-0029-1219144
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective In(III)-Catalyzed Ketone-Ene Reaction

Contributor(s): Mark Lautens, David A. Candito
J.-F. Zhao, T.-B. W. Tjan, B.-H. Tan, T.-P. Loh*
Nanyang Technological University, Singapore
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Publication History

Publication Date:
21 January 2010 (online)

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Significance

Building upon their previous work (J. Am. Chem. Soc. 2008, 130, 16492) the authors report on an indium(III)-pybox-based catalyst system of enhanced reactivity for the ketone-ene reactions of trifluoropyruvate, providing homoallylic alcohols with a quaternary stereocenter in high yield and enantioselectivity.