Copper-Mediated Amidation of Alkyltrifluoroborates with Nitriles

C. Cazorla; E. Métay; B. Andrioletti; M. Lemaire

doi:10.1055/s-0029-1219071

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Synfacts 2010(2): 0219-0219
DOI: 10.1055/s-0029-1219071

Metal-Mediated Synthesis

Copper-Mediated Amidation of Alkyltrifluoroborates with Nitriles

Contributor(s): Paul Knochel, Tobias Thaler
C. Cazorla, E. Métay, B. Andrioletti, M. Lemaire*
Université Lyon 1, Villeurbanne, France

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Publication History

Publication Date:
21 January 2010 (online)

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Significance

A mild Ritter-type Cu(OAc)₂- and BF₃×OEt₂-promoted amidation reaction using nitriles and alkyltrifluoroborates has been reported. Unlike other protocols for Ritter-type amidations which mostly involve high temperatures, this reaction proceeds already at room temperature.