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Synfacts 2010(2): 0211-0211
DOI: 10.1055/s-0029-1219068
DOI: 10.1055/s-0029-1219068
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Pt-Catalyzed Reduction of Carboxamides Using Hydrosilanes
S. Hanada, E. Tsutsumi, Y. Motoyama, H. Nagashima*
Kyushu University, Fukuoka, Japan
Further Information
Publication History
Publication Date:
21 January 2010 (online)
Significance
In this comprehensive article the platinum-catalyzed reduction of carbamides using hydrosilanes is described in detail. The reaction is highly chemoselective and proceeds with a remarkably high tolerance towards functional groups that are also prone to reduction, including cyano, ester and even nitro groups.