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Synfacts 2010(2): 0242-0242
DOI: 10.1055/s-0029-1219054
DOI: 10.1055/s-0029-1219054
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Aldol Reaction with Resin-Supported Ionic Liquids/l-Proline
Z. Wang, J. Yan, X. Zhang*, L. Wang*
Huaibei Coal Teachers College, Anhui Agricultural University, Hefei and Shanghai Institute of Organic Chemistry, P. R. of China
Further Information
Publication History
Publication Date:
21 January 2010 (online)
Significance
Merrifield resin-supported ionic liquid 1 was prepared by the treatment of Merrifieldresin with 1-methyl-1H-imidazole in toluene at 100 ˚C (eq. 1). l-Proline-catalyzed asymmetric aldol reaction of aldehydes 2 and ketones 3 proceeded in the presence of the polymeric ionic liquid 1 to give the corresponding aldol products 4 with up to 97% ee (18 examples, eq. 2).