Synthesis 2010(13): 2201-2206  
DOI: 10.1055/s-0029-1218818
© Georg Thieme Verlag Stuttgart ˙ New York

Chemical Probes for Labeling of the Bacterial Glucosaminidase NagZ via the Huisgen Cycloaddition

Ronald Orth, Maximilian Pitscheider, Stephan A. Sieber*
Center for Integrated Protein Science Munich CIPSM, Technische Universität München, Department of Chemistry, Lichtenbergstr. 4, 85747 Garching, Germany
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Received 6 April 2010
15.Juni 2010 (eFirst)


Glycoside hydrolases represent a large class of enzymes that cleave carbohydrate motifs. Since some enzymes play crucial roles in bacterial resistance pathways, we here introduce the synthesis and application of small sugar-based probes to study the function of the glycoside hydrolase NagZ.