Microwave-Assisted Synthesis of Nitro-Substituted Tetrahydropyrido­azepines

Abstract

The microwave-assisted condensation of azepan-4-ones with 3,5-dinitro-1-methylpyridin-2-one in the presence of ammonia was found to be a highly efficient method for the synthesis of nitro-substituted tetrahydropyridoazepines. Variation of the substituent at the amino group enables the regioselective synthesis of tetrahydropyrido[3,2-c]azepines and tetrahydropyrido[2,3-d]azepines.

ketones - condensation - regioselectivity - heterocycles - pyridines

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