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Synthesis 2010(5): 849-857  
DOI: 10.1055/s-0029-1218623
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Efficient One-Pot Synthesis of N-Substituted 2-Aminochromones, Their Benzo-Fused Derivatives, and Diaminobenzodipyrandiones of Two New Structural Classes

Giorgio Roma*, Daniela Piras, Mario Di Braccio, Giancarlo Grossi
Dipartimento di Scienze Farmaceutiche, Università di Genova, Viale Benedetto XV 3, 16132 Genova, Italy
Fax: +39(010)3538358; e-Mail: roma@unige.it;
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Publication History

Received 20 October 2009
Publication Date:
04 January 2010 (online)

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Abstract

N-Substituted 2-aminochromones and their benzo-fused derivatives were obtained in high yields by a new one-pot synthesis, starting from the appropriate acetamides, salicylic acid or its benzo-fused derivatives, and phosphoryl chloride. By the same reaction, from suitable dihydroxybenzenedicarboxylic acids, some compounds of two new structural classes, 2,7-diaminobenzo[1,2-b:4,5-b′]dipyran-4,9-diones and 2,8-diamino-4H,6H-benzo[1,2-b:5,4-b′]dipyran-4,6-diones, were synthesized.

Key words

amines - chromones - heterocycles - one-pot synthesis - pyrans

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