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Synthesis 2010(5): 858-862  
DOI: 10.1055/s-0029-1218610
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Catalyst-Free 1,3-Dipolar Cycloaddition: An Efficient Route for the Formation of the 1,2,3-Triazole-Fused Diazepinone Framework

K. C. Majumdar*, Krishanu Ray, Sintu Ganai, Tapas Ghosh
Department of Chemistry, University of Kalyani, Kalyani 741235, India
Fax: +91(33)25828282; e-Mail: kcm_ku@yahoo.co.in;
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Publication History

Received 2 November 2009
Publication Date:
16 December 2009 (online)

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Abstract

A catalyst-free, effective method for the synthesis of the hitherto unreported 1,2,3-triazole-fused diazepinone framework in good to excellent yield through 1,3-dipolar cycloaddition is reported. The generality of the reaction is demonstrated by the synthesis of an array of [1,2,3]triazolodiazepinones. The methodology offers a clean reaction and easy isolation of the products in good to excellent yield.

Key words

triazoles - diazepinones - 1,3-dipolar cycloaddition

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