Synlett 2009(18): 3048-3049  
DOI: 10.1055/s-0029-1218292
© Georg Thieme Verlag Stuttgart ˙ New York

CsOH×H2O in Organic Synthesis

Filipa Siopa*
REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal
Further Information

Publication History

Publication Date:
23 October 2009 (online)


Cesium hydroxide monohydrate (CsOH˙H2O) is an important reagent in organic synthesis being applied in a diversity of reactions. It is a solid strong base, commercially available, and it can be used in an assortment of solvents and reaction conditions.

Cesium hydroxide monohydrate allows the catalytic generation of highly reactive anions, which are able to add to carbonyl groups or carbon-carbon multiple bonds. Its great versatility as a base can be seen in a range of reactions as those involving carbon-carbon and carbon-­heteroatom bond formation. The increasing interest on CsOH˙H2O over the last few years, is patent on the diversity of applications, and the increased number of publications reporting its powerful basicity.


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