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Synfacts 2009(12): 1392-1392  
DOI: 10.1055/s-0029-1218178
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Zn-Cu Mediated Regioselective Addition of Propargyl Bromide to Carbonyls

Contributor(s): Paul Knochel, Andreas J. Wagner
X. Ma, J.-X. Wang*, S. Li, K.-H. Wang, D. Huang
Northwest Normal University, Lanzhou and Lanzhou University, P. R. of China
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Publikationsdatum:
20. November 2009 (online)

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Significance

A Barbier-type propargylation of ­aromatic and aliphatic aldehydes and ketones with propargyl bromide has been achieved under solvent-free conditions using a zinc-copper couple.