A Practical Synthesis of (S)-Cyclopent-2-enol

Abstract

An efficient and scalable procedure for the synthesis of (S)-cyclopent-2-enol is reported. The two key steps of the synthesis are the Noyori’s Ru-catalyzed transfer hydrogenation of an ynone and ring-closing metathesis of a 1,6-heptadiene.

asymmetric synthesis - transfer hydrogenation - ring-closing metathesis - allylic alcohol

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