Synthesis 2010(3): 538-542  
DOI: 10.1055/s-0029-1217102
PSP
© Georg Thieme Verlag Stuttgart ˙ New York

A Practical Method for O-Acylation of N-Hydroxythiazole-2(3H)-thiones

Christine Schur, Andreas Groß, Jens Hartung*
Fachbereich Chemie, Organische Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger-Straße, 67663 Kaiserslautern, Germany
Fax: +49(631)2053921; e-Mail: [email protected];
Further Information

Publication History

Received 24 July 2009
Publication Date:
06 November 2009 (online)

Abstract

O-Acylation of 4- and 4,5-substituted N-hydroxythiazole-2(3H)-thiones occurred in solutions of acetone upon treatment with solid K2CO3 and a variety of neat acyl chlorides (primary, secondary, and tertiary alkyl, aryl; 60-87% yield; ∼10 g scale).

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