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Synthesis 2009(19): 3233-3242
DOI: 10.1055/s-0029-1216957
DOI: 10.1055/s-0029-1216957
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
3-(Polyfluoroacyl)chromones and Their Hetero Analogues as Valuable Substrates for Syntheses of 4-(Polyfluoroalkyl)pyrimidines
Weitere Informationen
Received
23 February 2009
Publikationsdatum:
21. August 2009 (online)
Publikationsverlauf
Publikationsdatum:
21. August 2009 (online)
Abstract
Reactions of 3-(polyfluoroacyl)chromones and their hetero analogues with a number of 1,3-NCN-dinucleophiles, such as amidines or guanidines, were studied in detail, and preparative access to a set of diverse 5-salicyloyl-4-(polyfluoroalkyl)pyrimidines was elaborated. These compounds appear to be a suitable starting substrates for the synthesis of 4-(polyfluoroalkyl)pyrimidine-5-carboxylic acids or pyrimidines containing a benzofuran-3-yl substituent in the 5-position.
Key words
chromones - thiochromones - fluorine - pyrimidine core annulation - regioselectivity - heterocycles
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