Horm Metab Res 2009; 41(8): 626-629
DOI: 10.1055/s-0029-1216359
Humans, Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Low Serum Adiponectin Predicts 10-Year Risk of Type 2 Diabetes and HbA1c Independently of Obesity, Lipids, and Inflammation: Whitehall II Study

A. G. Tabák 1 , 2 , E. J. Brunner 1 , M. A. Miller 3 , S. Karanam 3 , P. G. McTernan 3 , F. P. Cappuccio 3 , D. R. Witte 1 , 4
  • 1Department of Epidemiology and Public Health, University College London, London, UK
  • 2Semmelweis University, Budapest, Hungary
  • 3Clinical Sciences Research Institute, Warwick Medical School, Coventry, UK
  • 4Steno Diabetes Center, Gentofte, Denmark
Further Information

Publication History

received 26.11.2008

accepted 02.03.2009

Publication Date:
15 April 2009 (eFirst)

Abstract

Our aim of the present work was to study the effect of serum adiponectin on incident diabetes and HbA1c values. We measured baseline serum adiponectin levels in a nested case-control selection (n=140) of the Whitehall II Cohort. Participants (mean [SD] age 50.9 [6.3] years) had no prevalent diabetes or CHD at baseline. Cases (n=55) had incident diabetes according to an oral glucose tolerance test during follow-up (mean: 11.5±3.0 years). Adiponectin levels were lower among cases (9.3 μg/ml, 3.2 [median; IQR] vs. 10.5; 3.6, p=0.01). The risk of incident diabetes decreased by 11% (p=0.03) for 1 μg/ml higher adiponectin levels. Higher adiponectin levels were associated with lower HbA1c at follow-up (p<0.05). Both associations were stable to adjustment for age, sex, body mass index, systolic blood pressure, and serum lipids, and for the case of HbA1c, also for C-reactive protein (all p<0.05). The observed robust, prospective associations support that adiponectin is an independent predictor of diabetes and the degree of glycaemic impairment.

References

Correspondence

A. G. Tabák, MD 

Department of Epidemiology and Public Health

University College London

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Email: a.tabak@ucl.ac.uk