Endoscopy 2010; 42: E22-E23
DOI: 10.1055/s-0029-1215352
Unusual cases and technical notes

© Georg Thieme Verlag KG Stuttgart · New York

Cytomegalovirus-esophagitis as initial presentation of HIV infection mimicking adenocarcinoma

G.  Weinberg1 , B.  Siegmund2 , M.  Grünbaum3 , C.  Loddenkemper3 , T.  Schneider4
  • 1Department of Nephrology and Intensive Care Medicine, Charite Campus Virchow Klinikum, Berlin, Germany
  • 2Department of Gastroenterology, Charite Campus Benjamin Franklin, Berlin, Germany
  • 3Department of Pathology, Charite Campus Benjamin Franklin, Berlin, Germany
  • 4Department of Infectious Diseases, Charite Campus Benjamin Franklin, Berlin, Germany
Further Information

Publication History

Publication Date:
13 January 2010 (online)

A 49-year-old man presented with dysphagia and weight loss of 5 kg within 2 months. An esophagogastroduodenoscopy (EGD) was performed in a community hospital. An ulcerated tumor of the cardia was seen and a biopsy was interpreted as a well-differentiated adenocarcinoma. The patient was referred to our hospital to complete the staging and initiate surgical intervention. The EGD was repeated and the previously described cardiac tumor was confirmed ([Fig. 1]).

Fig. 1 Edge (left arrow) and ulcerated field (right arrow) of a tumor mass.

An endoscopic ultrasound (EUS) revealed a 30 × 8 mm tumor ([Fig. 2]).

Fig. 2 Endoscopic ultrasound showed an intact muscular layer.

The mucosal and submucosal layers could not be delineated but the muscular layer was intact. The macroscopic view resulted in the diagnosis of an early gastric cancer uT1sm and consequently surgical management was considered. In addition, the histologic examination revealed a damaged mucosal architecture and epithelial cells with atypia. In parallel, the medical history revealed homosexual preferences of the patient; HIV-testing was initiated. The viral load was 464 000/copies/mL and CD4 T-cell count was 30/µL. Because of the novel aspect of an immunosuppressive state, the diagnosis of cytomegalovirus (CMV)-gastroesophagitis was considered, and we requested the biopsies from the local pathology center for re-evaluation. Immunhistochemical examination of all biopsies indicated the presence of multiple CMV pp65-positive cells ([Fig. 3]).

Fig. 3 Histologic examination and immunohistochemical staining showed cytomegalovirus-positive cells.

The most common presentation of CMV-esophagitis are well-circumscribed ulcerations, which can differ in number, size, and depth [1]. Although the appearance is endoscopically highly variable, an ulcerated, bulged, and irregularly circumscribed tumor is a rare condition. The surgical intervention was delayed and treatment with ganciclovir was initiated. After CMV therapy EGD and EUS were repeated. Only a small ulcer of the cardia remained and EUS was normal. The histologic investigation revealed inflammation and mild regenerative features ([Fig. 4]).

Fig. 4 Regeneration of cytoarchitecture after treatment for cytomegalovirus.

In summary this case demonstrates the difficulties in differentiating between an inflammatory process and an invasive tumor by endoscopy, ultrasound, and histology [2] [3], and underlines the importance of a detailed medical history. By re-evaluating the diagnosis, the patient was saved from an esophagocardiac resection.



G. Weinberg, MD 

Department of Nephrology and Intensive Care Medicine
Charite Universitätsmedizin Berlin
Campus Virchow Klinikum

Augustenburger Platz 1
13353 Berlin

Fax: +49-30-450565954

Email: gordon.weinberg@charite.de