Endoscopy 2010; 42: E73-E74
DOI: 10.1055/s-0029-1215204
Unusual cases and technical notes

© Georg Thieme Verlag KG Stuttgart · New York

Lymphoepithelioma-like gastric carcinoma resected by endoscopic submucosal dissection (ESD)

H.  S.  Moon1 , S.  H.  Kang1 , J.  K.  Seong1 , H.  Y.  Jeong1 , K.  S.  Song2
  • 1Department of Internal Medicine, Chung Nam University College of Medicine, Daejeon, South Korea
  • 2Department of Pathology, Chung Nam University College of Medicine, Daejeon, South Korea
Further Information

Publication History

Publication Date:
01 March 2010 (online)

We report here a rare case of lymphoepithelioma-like gastric carcinoma that presented as a flat depressed lesion and was treated by complete en-bloc resection using endoscopic submucosal dissection (ESD).

A 73-year-old man was referred to the department of internal medicine because of an incidental finding suspicious of early gastric cancer. The patient’s medical history and laboratory test results were unremarkable. Gastroscopy revealed an erythematous, flat depressed lesion in the posterior wall of the upper part of the gastric body ([Fig. 1]).

Fig. 1 Endoscopy showed an erythematous, flat depressed lesion in the posterior wall of the upper body of the stomach.

No abnormalities were detected on abdominal computed tomography. The tumor was removed completely by ESD, using an insulation-tipped knife (KD-610L; Olympus, Tokyo, Japan) ([Fig. 2]).

Fig. 2 a The lesion was resected by endoscopic submucosal dissection (ESD) using an insulation-tipped knife. b The resected tumor was 19 × 14 mm in size.

Histopathological findings of the resected specimen were compatible with the diagnosis of lymphoepithelioma-like gastric carcinoma ([Fig. 3]).

Fig. 3 a Histological examination of the resected specimen revealed that the mass was located in the subepithelial area (hematoxylin and eosin [H&E], magnification × 20). b Nests of tumor cells separated by dense lymphoplasmacytic infiltration (H&E, magnification × 200). Immunohistochemical staining was positive for: (c) cytokeratin; and (d) leucocyte common antigen (LCA; CD 45).

Lymphoepithelioma-like gastric carcinoma is a rare type of gastric carcinoma, constituting about 4 % of all gastric carcinomas [1]. It is characterized by the presence of a lymphoid stroma and small nests of cancer cells that are uniformly distributed throughout the lymphoid stroma. There is clear demarcation between the tumor nests and the nondesmoplastic lymphocyte-rich stroma, as is the case with lymphoid tissue. Lymphoepithelioma-like gastric carcinoma has a good prognosis and is closely associated with the presence of the Epstein-Barr virus and microsatellite instability [2]. The recently introduced technique of ESD can be useful in the diagnosis and treatment of early gastric cancer. In particular, this method enables en-bloc resection of the tumor, regardless of tumor size and location.

In our case, endoscopic examination of the flat depressed lesion revealed an appearance typical of early gastric adenocarcinoma. However, the histological examination revealed that the tumor was a lymphoepithelioma-like gastric carcinoma.



Dr. H. S. Moon

Department of Internal Medicine
Chung Nam University College of Medicine

Dae Sa Dong, 640
South Korea

Fax: +82-42-2544553

Email: mhs1357@cnuh.co.kr