Background and study aims: The clinicopathologic features of gastric cancers containing a mixture of differentiated-type
and undifferentiated-type components remain uninvestigated. We evaluated the risk
of lymph node metastasis and the feasibility of endoscopic submucosal dissection (ESD)
for the treatment of mixed-histologic-type gastric cancers.
Patient and methods: We histologically classified 376 cases of gastric cancer with submucosal invasion
into four types (differentiated type, differentiated-type-predominant mixed type,
undifferentiated-type-predominant mixed type, and undifferentiated type) and studied
the clinicopathologic relations of each type to lymph node metastasis. Lymphatic invasion
was evaluated by D2 – 40 immunostaining.
Results: The overall prevalence of lymph node metastasis in gastric cancer with submucosal
invasion was 16.5 % (62 / 376). The prevalence of lymph node metastasis was 36.5 %
(23 / 63) in undifferentiated-type-predominant mixed type, which was significantly
higher than those in the other three types (P < 0.001 vs. differentiated type, P = 0.013 vs. differentiated-type-predominant mixed type, and P = 0.003 vs. undifferentiated type). Lymphatic invasion, a depth of invasion of 500 µm
or more from the lower margin of the muscularis mucosae (SM2), tumor size above 30 mm,
and undifferentiated-type-predominant mixed histologic type were independent risk
factors for lymph node metastasis. Submucosal cancers without these four risk factors
were free of lymph node metastasis (0 / 41; 95 % confidence interval 0 % – 8.6 %).
Conclusions: Undifferentiated-type-predominant mixed-type gastric cancer with submucosal invasion
carries a high risk of lymph node metastasis. ESD can be indicated for gastric cancer
with submucosal invasion provided that the following conditions indicating a low risk
of metastasis are met: a depth of invasion of no more than 500 µm or more from the
lower margin of the muscularis mucosae (SM1), no lymphatic invasion, a tumor size
of no more than 30 mm, and a proportion of undifferentiated components below 50 %.
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N. HanaokaMD
Department of Gastroenterology
Kitasato University School of Medicine
2-1-1 Asamizodai
Sagamihara-City
Kanagawa 228-8520
Japan
Fax: +81-42-7484288
eMail: noboley1121@aol.com
