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Exp Clin Endocrinol Diabetes 1998; 106(6): 475-477
DOI: 10.1055/s-0029-1212019
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The effect of clozapine on glucose metabolism

K. M. Yazici1 , T. Erbas2 , A. H. Yazici1
  • 1Department of Psychiatry, Hacettepe University Faculty of Medicine Ankara, Turkey
  • 2Department of Endocrinology and Metabolism, Hacettepe University Faculty of Medicine Ankara, Turkey
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Publikationsdatum:
14. Juli 2009 (online)

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Summary

Although there have been several reports that clozapine precipitated hyperglycemia and diabetic ketoacidosis in some patients, the mechanism by which clozapine impairs glucose metabolism is not known. This study investigated the effect of clozapine on glucose metabolism in six schizophrenic patients while they were free of medication and receiving 200 mg/d and 450 mg/d of clozapine. Clozapine increased mean levels of blood glucose, insulin and C-peptide. It is possible, based on these findings, that the glucose intolerance was due to increased insulin resistance.

Key words

Clozapine - diabetes mellitus - hyperglycemia