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Exp Clin Endocrinol Diabetes 1996; 104: 17-20
DOI: 10.1055/s-0029-1211673
Autoimmune thyroiditis - induction models

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The non-obese diabetic (NOD) mouse: An animal model for autoimmune thyroiditis

Marie-Christine Many, Serge Maniratunga, Jean-François Denef
  • Laboratory of Histology, Medical School, Catholic University of Louvain, Brussels, Belgium
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Publication Date:
15 July 2009 (online)

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Summary

The NOD mouse, an ideal model for insulin-dependent diabetes mellitus, is also useful to study the pathogenesis of autoimmune thyroiditis. Spontaneous thyroiditis greatly varies in frequency among NOD colonies, but Hashimoto-like thyroiditis can be induced in two experimental models: goiter involution after iodide administration and immunization by TSH receptor, described hereunder.

Key words

NOD mouse - thyroiditis - autoimmunity