Exp Clin Endocrinol Diabetes 1996; 104(4): 311-316
DOI: 10.1055/s-0029-1211460

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

A Benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy

H. Stracke, A. Lindemann, K. Federlin
  • Third Medical Department, University of Giessen, Germany
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Publication History

Publication Date:
15 July 2009 (online)


In a double-blind, randomized, controlled study, the effectiveness of treatment with a combination of Benfotiamine (an Allithiamine, a lipid-soluble derivative of vitamin B1 with high bioavailability) plus vitamin B6/B12 on objective parameters of neuropathy was studied over a period of 12 weeks on 24 diabetic patients with diabetic polyneuropathy.

The results showed a significant improvement (p = 0.006) of nerve conduction velocity in the peroneal nerve and a statistical trend toward improvement of the vibration perception threshold. Long-term observation of 9 patients with verum over a period of 9 months support the results. Therapy-specific adverse effects were not seen. The results of this double-blind investigation, of the long-term observation and of the reports in the literature support the contention that the neurotropic benfotiamine-vitamin B combination represents a starting point in the treatment of diabetic polyneuropathy.