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Exp Clin Endocrinol Diabetes 1994; 102(2): 94-97
DOI: 10.1055/s-0029-1211269
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Urinary excretion of hydroxy-pyridinium cross-links of collagen reflects skeletal growth velocity in normal children

F. Rauch1 , E. Schönau1 , H. Woitge2 , T. Remer3 , M. Seibel2
  • 1Children's Hospital, University of Cologne, Germany
  • 2Dept. of Medicine, Div. of Endocrinology and Metabolism, University of Heidelberg, Germany
  • 3Research Institute of Child Nutrition, Dortmund, Germany
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Publication History

Publication Date:
15 July 2009 (online)

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Summary

Two new markers of bone resorption, the Collagen cross-linking amino acids pyridinoline (PYD) and deoxypyridinoline (DPD), were measured in 24-h urine collections from 88 healthy children (45 females, 43 males; age 4 to 18 years) and 17 adults. Normal values for pediatric use were established for these Parameters. Related to daily excretion of Creatinine PYD and DPD were about 3 to 6 fold higher in the pediatric groups than in adults. The collagen cross-links showed a highly significant correlation to the urinary excretion of hydroxyproline (OHP): r = 0.65 for PYD and r = 0.60 for DPD (p < 0.001). Both collagen cross-links and OHP excretion related to Creatinine were significantly correlated to growth velocity (r = 0.67, 0.62 and 0.51 for PYD, DPD and OHP respectively; p < 0.001 in each case). PYD and DPD may be useful for the monitoring of growth in children.

Key words

Bone resorption - collagen cross-links - growth velocity - normal children - pyridinoline

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