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Exp Clin Endocrinol Diabetes 1992; 100(6): 145-147
DOI: 10.1055/s-0029-1211195
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Influence of the Electrical Stimulation of the Medial Amygdala on Adrenocortical Sensitivity to Adrenocorticotrophin in Hypophysectomized Rats

H. Saito, T. Sato, H. Kaba, F. Okutani, G.-Z. Yu, K. Seto, F. Kimura1 , M. Kawakami1 , S. Roberts2
  • Department of Physiology, Kochi Medical School, Nankoku
  • 1Department of Physiology, Yokohama City University School of Medicine, Yokohama/Japan
  • 2Department of Biological Chemistry, UCLA School of Medicine, LA/U.S.A.
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Publication History

Publication Date:
16 July 2009 (online)

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Summary

The effects of electrical stimulation of medial amygdala on the adrenocortical sensitivity to adrenocorticotrophin (ACTH) were investigated in hypophysectomized rats. The intravenous injection of ACTH increased the rates of 14C transfer from 14C-1-acetate into corticosterone and cortisol in the adrenal slices of hypophysectomized rats. The electrical stimulation of the medial amygdala produced a further increase in the rates of 14C transfer from 14C-1-acetate into corticosterone and cortisol. From these results, it might be suggested that the medial amygdala was capable of enhancing the adrenocortical steroidogenesis in response to ACTH.

Key words

Amygdala - Adrenocortical Steroids - Adrenocorticotrophin - Hypophysectomized rats

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