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Exp Clin Endocrinol Diabetes 1992; 99(2): 96-98
DOI: 10.1055/s-0029-1211144
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Hypothermia in Insulin-Treated Obese Rats

H. Shimizu, N. Sato, Y. Uehara, Y. Shimomura
  • First Department of Internal Medicine, Gunma University School of Medicine, Maebashi/Japan
Further Information

Publication History

1991

Publication Date:
15 July 2009 (online)

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Summary

Changes of colonic temperature were investigated to examine a mechanism of hypothermia in the obese rats which received subcutaneous administration of intermediate type-insulin (8 U/day) for 8 weeks. Although diurnal rhythmicity of colonic temperature levels was maintained similarly with those of vehicle-injected controls, the overall colonie temperature levels were significantly lowered in insulin-treated animals. In the condition of cold exposure at 5 °C, colonie temperature levels of insulin-treated animals were immediately and significantly decreased at 60 minutes after the start of cold exposure. The data obtained herein demonstrated that hyperinsulinemia accompanying with hyperphagia should be profoundly involved in hypothermia, observed in various experimental models of obesity.

Key words

Insulin - Obesity - Body temperature - Rat

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