Influence of Dorsal Hippocampal Stimulation and Dorsal Fornix Lesions on Hepatic Glucose Metabolism in Rabbits

H. Saito; H. Kaba; T. Sato; K. Nojima; C.-S. Li; K. Seto; F. Kimura; M. Kawakami

doi:10.1055/s-0029-1210997

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Exp Clin Endocrinol Diabetes 1990; 96(4): 113-116
DOI: 10.1055/s-0029-1210997

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Influence of Dorsal Hippocampal Stimulation and Dorsal Fornix Lesions on Hepatic Glucose Metabolism in Rabbits

H. Saito, H. Kaba, T. Sato, K. Nojima, C.-S. Li, K. Seto, F. Kimura¹ , M. Kawakami¹

Department of Physiology (Chairman: Prof. K. Seto), Kochi Medical School, Nankoku
¹Department of Physiology (Chairman: Prof. F. Kimura) Yokohama City University School of Medicine, Yokohama, Japan

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Publication History

1989

Publication Date:
16 July 2009 (online)

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Summary

We examined the effects of stimulation of the dorsal hippocampus and lesions of the dorsal fornix on glucose metabolism in liver slices of rabbits. Hippocampal stimulation decreased the ¹⁴C transfer rates from ¹⁴C-glucose into C0₂, ketone bodies, cholesterol ester and free fatty acids, but increased the rates into triglyceride, phospholipids and glycogen. Fornix lesions had various effects on glucose metabolism, and the effects of hippocampal stimulation on glucose metabolism were abolished by fornix lesions. These observations support the hypothesis that the hippocampus is an integral part of the brain regulator system in the hepatic glucose metabolism.

Key words

Hippocampus - Glucose metabolism - Rabbit's liver