Summary
Ovarian follicular fluid peptide (OFFP) has earlier been shown to inhibit maturation
of large follicles and ovulation in mice. An active fraction hGF2, obtained following
partial purification from human ovarian follicular fluid, was injected at a dose of
20 μg to 4-month-old immature marmosets, every alternate day for 2 months. The animals
were autopsied at 4 and 6 months of age. Ovarian morphology indicated the appearance
of large follicles at 6 months of age in the control group. In contrast, in hGF2 treated
marmosets development up to preantral follicles could be seen at 6 months. Furthermore,
only in 1 out of the 5 treated marmosets, presence of large preantral follicles was
observed and in the remaining 4 animals only primary and secondary follicles were
noted. These results reveal that OFFP suppresses follicular development and antrum
formation in marmosets.
Key words
Ovarian follicular fluid - Antral follicles - Marmoset
